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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
13.03
Human Site:
S585
Identified Species:
23.89
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S585
G
G
L
G
G
G
P
S
A
W
E
A
C
P
P
Chimpanzee
Pan troglodytes
XP_509099
871
93967
V599
L
P
G
L
R
T
A
V
P
P
H
E
P
G
G
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
E618
G
G
G
P
S
A
W
E
A
C
P
P
A
L
R
Dog
Lupus familis
XP_857182
860
93116
S585
G
G
L
G
G
G
P
S
A
W
E
A
C
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
S618
G
G
L
G
V
G
P
S
A
W
D
A
C
P
P
Rat
Rattus norvegicus
Q63796
888
96289
T618
G
G
L
G
V
G
P
T
A
W
D
A
S
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
G631
H
N
H
S
H
H
P
G
L
P
Q
Q
H
G
H
Frog
Xenopus laevis
A7J1T0
961
107551
P631
Q
H
Q
T
P
A
S
P
P
V
T
P
C
S
P
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
A587
P
K
H
P
S
A
P
A
S
R
E
R
E
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
P620
S
G
G
A
G
G
T
P
A
T
P
L
L
Y
P
Honey Bee
Apis mellifera
XP_397605
895
101116
T604
F
V
D
N
Q
T
Q
T
D
I
M
D
I
N
E
Nematode Worm
Caenorhab. elegans
O01700
928
103465
G609
G
M
W
S
A
G
A
G
S
C
T
A
I
N
G
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
A604
T
S
S
N
P
R
A
A
D
E
D
V
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
0
20
100
N.A.
86.6
73.3
N.A.
N.A.
6.6
13.3
20
N.A.
33.3
0
20
0
P-Site Similarity:
100
0
20
100
N.A.
93.3
86.6
N.A.
N.A.
13.3
13.3
33.3
N.A.
33.3
6.6
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
24
24
16
47
0
0
39
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
16
0
0
31
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
16
0
24
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
0
8
24
8
8
0
8
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
47
47
24
31
24
47
0
16
0
0
0
0
0
16
16
% G
% His:
8
8
16
0
8
8
0
0
0
0
8
0
8
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
16
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
0
31
8
0
0
0
0
8
0
0
8
8
8
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
8
0
16
0
0
0
0
0
0
0
0
0
16
0
% N
% Pro:
8
8
0
16
16
0
47
16
16
16
16
16
8
39
47
% P
% Gln:
8
0
8
0
8
0
8
0
0
0
8
8
0
0
0
% Q
% Arg:
0
0
0
0
8
8
0
0
0
8
0
8
0
0
8
% R
% Ser:
8
8
8
16
16
0
8
24
16
0
0
0
16
16
8
% S
% Thr:
8
0
0
8
0
16
8
16
0
8
16
0
0
0
0
% T
% Val:
0
8
0
0
16
0
0
8
0
8
0
8
0
0
8
% V
% Trp:
0
0
8
0
0
0
8
0
0
31
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _